RESEARCH ARTICLE


The Integrated Web Portal for Escalation with Overdose Control (EWOC)



Haibin Wang*, Mourad Tighiouart, Shao-Chi Huang, Dror Berel, Galen Cook-Wiens, Catherine Bresee, Quanlin Li , André Rogatko
Biostatistics & Bioinformatics Research Center, Cedars-Sinai Medical Center, 116 N. Robertson Blvd, Los Angeles, CA 90048, USA


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© Wang et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Biostatistics & Bioinformatics Research Center, Cedars-Sinai Medical Centre, 116 N. Robertson Blvd, Los Angeles, CA 90048, USA; Tel: 310-423-3315; Fax: 310-423-3315; E-mail: Haibin.wang@cshs.org


Abstract

In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu.

Keywords: EWOC, Bayesian method, cancer phase I clinical trial, maximum tolerated dose, open source.