The Integrated Web Portal for Escalation with Overdose Control (EWOC)
Haibin Wang*, Mourad Tighiouart, Shao-Chi Huang, Dror Berel, Galen Cook-Wiens, Catherine Bresee, Quanlin Li , André Rogatko
Identifiers and Pagination:Year: 2013
First Page: 18
Last Page: 23
Publisher Id: TOMINFOJ-7-18
Article History:Received Date: 2/1/2013
Revision Received Date: 15/4/2013
Acceptance Date: 20/4/2013
Electronic publication date: 31/5/2013
Collection year: 2013
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu.